Publications

Euliano EM, Pogostin BP, Agrawal A, Yu MH, Baryakova TH, Graf TP, Hartgerink JD, McHugh KJ*. A TLR7 agonist conjugated to a nanofibrous peptide hydrogel as a potent vaccine adjuvant. In revision at Advanced Healthcare Materials. Download preprint here.

Euliano EM, Agrawal A, Yu MH, Graf TP, Henrich EM, Kunkel AA, Chia-Chien H, Baryakova T, McHugh KJ*. Intra-lymph node crosslinking of antigen-bearing polymers enhances humoral immunity and dendritic cell activation. In revision at Bioengineering & Translational Medicine. Download preprint here.

Bice MLL, Ortega VL, Yu MH, McHugh KJ. Methacrylated poly(glycerol sebacate) as a photocurable, biocompatible, and biodegradable polymer with tunable degradation and drug release kinetics. In revision at Drug Delivery and Translational Research. Download preprint here.

Pogostin BH, Wu SX, Swierczynski MJ, Pennington D, Li SY, Vohidova D, Seeley EH, Agrawal A, Tang C, Cabler J, Dey A, Veiseh O, Nuermberger EL, Ball ZT, Hartgerink JD, McHugh KJ. Enhanced dynamic covalent chemistry for the controlled release of small molecules and biologics from a peptide hydrogel platform. Download preprint here.

Deogharia M, Venegas-Zamora L, Agrawal A, Shi M, Jain A, McHugh KJ, Altamirano F, Marian AJ, Gurha P. Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization. Cardiovascular Research 2024:cvae014. Download here.

Dixit DD, TP Graf, McHugh KJ, Lillehoj PB. Microfluidic device for flow-based immune cell quantification in whole blood using machine learning. IEEE 37th International Conference on Micro Electro Mechanical Systems (MEMS) 2024. Conference Proceeding. Download here.

Collins J, Sarmadi M, Allison-Logan S, Han J, vander Straeten A, Perkinson CF, Acolaste S, Kanelli M, Daristotle J, Karchin A, Henderson M, Wood L, Jing L, McHugh KJ, Cruz M, Artzi D, Bawendi MG, Langer R, Jaklenec A. On-Patient Temporary Medical Record for Accurate, Time-Sensitive Information at the Point of Care. Advanced Functional Materials 2024:2311821. Download here.

Zhang P, Jiao M, Li Y, Ding X, McHugh KJ, Jing L. Bright semiconductor quantum dots shed new light on precision nanomedicine for various diseases. Small Science 2023:2300081. Download here.

Kunkel A, McHugh KJ. Injectable Controlled-Release Systems for the Prevention and Treatment of Infectious Diseases. Journal of Biomedical Materials Research Part A 2024;8:1124. Download here.

Shi M, McHugh KJ. Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems. Advanced Drug Delivery Reviews 2023;199:114904. Download here.

Duan F, Jia Q, Liang G, Wang M, Zhu L, McHugh KJ, Jing L, Du M, Zhang Z. Schottky junction nanozyme based on Mn-bridged co-phthalocyanines and Ti3C2Tx nanosheets boosts integrative type-I and II photosensitization for multimodal cancer therapy. ACS Nano 2023;17:11290-11308. Download here.

Graf TP, Kadasia K, Melhorn S, Kessler E, Yang H, Baryakova T, Brady S, McHugh KJ. Fabrication of pulsatile polymeric microparticles encapsulating rabies antigen. Journal of Visualized Experiments 2023;195:e65147. Download here.

Baryakova TH, Pogostin BH, Langer R, McHugh KJ. Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems. Nature Reviews Drug Discovery. Featured by Science. Download here.

Graf TP, Qiu S, Varshney D, Laracuente ML, Euliano EM, Munnangi P, Pogostin BP, Baryakova TH, Garyali A, McHugh KJ. A scalable platform for fabricating biodegradable microparticles with pulsatile release. Advanced Materials 2023:e2300228. Download here.

Pogostin BH, Saenz G, Cole CC, Euliano EM, Hartgerink J, McHugh KJ. Dynamic imine bonding facilitates mannan release from a nanofibrous peptide hydrogel. Bioconjugate Chemistry 2023;34:193-203. Download here.

Tang W, Zhuang J, Anselmo AC, Xu X, Duan A, Zhang R, Sugarman JL, Zeng YY, Rosenberg E, Graf T, McHugh KJ, Tzeng SY, Behrens AM, Freed LE, Jing L, Jayawardena S, Weinstock S, Le X, Sears C, Oxley J, Daristotle JL, Collins J, Langer R, Jaklenec A. Enhanced heat and oxidative stability and absorption of a new form of encapsulated vitamin A for food fortification: a randomized controlled crossover trial in women. PNAS 2022;119:e2211534119. Download here.

Schwabkey Z, Chang CC, Jamal M, Karmouch J, Wiesnoski D, Ahmed SS, Alousi A, Champlin R, Do KA, Frenk Oquendo A, Galloway-Pena JR, Halsey T, Hayase E, Hayase T, Jensen V, Jin Y, Lorenzi P, Mehta R, Molldrem J, Peterson C, Pham D, Sanchez CA, Shelburne S, Shi Y, Shpall E, Srour SA, Tan L, Tsai WB, Zhang L, Burgos da Silva M, Daniel C, Okhuysen P, Peled J, Rondon G, Shono Y, van den Brink M, Wang Y, Wargo J, Warmoes M, Ajami N, Brown A, El-Himri R, Graf T, McHugh K, Fowler S, Conner M, Swennes A, Heckel B, Miyama T, Ortega Turrubiates M, Raybaud M, Jenq RR. Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment. Science Translational Medicine 2022;14(671):eabo3445. Download here.

Euliano EM, Sklavounos AA, Wheeler AR, McHugh KJ. Translating Diagnostics and Drug Delivery Technologies to Low-Resource Settings. Science Translational Medicine 2022;14:eabm1732. Download here.

Pogostin, BH, Yu MH, Azares AR, Euliano EM, Lai CSE, Saenz G, Wu SX, Farsheed AC, Melhorn SM, Graf TP, Woodside DG, Hartgerink JD, McHugh KJ. Multidomain peptide hydrogel adjuvants potentiate strongly biased humoral immunity. Biomaterials Science 2022;10:6217-29. Download here.

Zhang P, Li Y, Tang W, Zhao J, Jing L, McHugh KJ. Theranostic nanoparticles with disease-specific administration strategies. Nano Today 2022;42:101335. Download here.

Pogostin BH, McHugh KJ. Novel vaccine adjuvants as key tools for improving pandemic preparedness. Bioengineering 2021;8:155. Download here.

Zhang P, Meng J, Li Y, Yang C, Hou Y, Tang W, McHugh KJ, Jing L. Nanotechnology-enhanced immunotherapy for metastatic cancer. The Innovation 2021;2,100174. Download here.

Varshney D, Qiu SY, Graf TP, McHugh KJ. Employing Drug Delivery Strategies to Overcome Challenges using TLR7/8 Agonists for Cancer Immunotherapy. AAPS J 2021;23:90. Found here.

Munoz N, Williams M, Dixon K, Dupuis C, McWatters A, Avritscher R, Marique S, McHugh K, Murthy R, Tam A, Naing A, Patel S, Leach D, Hartgerink J, Young S, Prakash P, Hwu P, Sheth R. Influence of injection technique, drug formulation, and tumor microenvironment on intratumoral immunotherapy delivery and efficacy. J Immunother Cancer 2021;9:e001800. Download here.

Laracuente, M.-L.; Yu, M. H.; McHugh, K. J. Zero-Order Drug Delivery: State of the Art and Future Prospects. Journal of Controlled Release 2020, 327, 834–856. Download here.

Lu X, Miao L, Gao W, Chen Z, McHugh KJ, Sun Y, Tochka Z, Tomasic S, Sadtler K, Hyacinthe A, Huang Y, Graf T, Hu Q, Sarmadi M, Langer R, Anderson DG, Jaklenec A. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Sci Transl Med 2020;12:eaaz6606. Cover Article. Download here.

Sarmadi M, Behrens AM, McHugh KJ, Contreras H, Tochka Z, Lu X, Langer R, Jaklenec A. Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Sci Adv 2020;6:eabb6594. Download here.

McHugh KJ. Employing drug delivery strategies to create safe and effective pharmaceuticals for COVID-19. Bioeng Transl Med 2020;5:e10163. Download here.

McHugh KJ, Jing L, Severt SY, Cruz M, Sarmadi M, Jayawardena HSN, Perkinson CF, Larusson F, Rose S, Tomasic S, Graf T, Tzeng SY, Sugarman JL, Vlasic D, Peters M, Peterson N, Wood L, Tang W, Yeom J, Collins J, Welkhoff PA, Karchin A, Tse M, Gao M, Bawendi MG, Langer R, Jaklenec A. Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination. Sci Transl Med 2019;11:eaay7162. Cover Article. Featured by Scientific American, Rice News, MIT News, STAT, and others. Download here.

Anselmo AC, Xu X, Buerkli S, Zeng Y, Tang W, McHugh KJ, Behrens AM, Rosenberg E, Duan AR, Sugarman JL, Zhuang J, Collins J, Lu X, Graf T, Tzeng SY, Rose S, Acolatse S, Nguyen TD, Le X, Guerra AS, Freed LE, Weinstock SB, Sears CB, Nikolic B, Wood L, Welkhoff PA, Oxley JD, Moretti D, Zimmermann MB, Langer R, Jaklenec A. A heat-stable microparticle platform for oral micronutrient delivery. Sci Transl Med 2019;11:eaaw3680. Cover Article. Featured by NPR, New Scientist, Science Daily, MIT News, and Chemical & Engineering News. Download here.

Yeom J, Puimaraes PPG, Ahn HM, Jung BK, Hu Q, McHugh K, Mitchell MJ, Yun CO, Langer R, Jaklenec A. Chiral supraparticles for controllable nanomedicine. Adv Mater 2019;31:e1903878. Featured by MIT News, Science Daily, and PhysOrg. Download here.

McHugh KJ, Li D, Wang JC, Kwark L, Loo J, Macha V, Farsiu S, Kim LA, Saint-Geniez M. Computational modeling of retinal hypoxia and photoreceptor degeneration in patients with age-related macular degeneration. PLoS One;14:e0216215. Download here.

Tzeng SY, McHugh KJ, Behrens A, Rose S, Ferber S, Langer R, Jaklenec A. Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response. Proc Natl Acad Sci USA 2018;115:E5269-78. Download here.

McHugh KJ, Jing L, Behrens AM, Jayawardena S, Tang W, Gao M, Langer R, Jaklenec A. Biocompatible semiconductor quantum dots as cancer imaging agents. Adv Mater 2018;30:e1706356. Download here.

Ferber S, Behrens AM, McHugh KJ, Rosenberg EM, Linehan AR, Sugarman JL, Jayawardena HSN, Langer R, Jaklenec A. Evaporative Cooling Hydrogel Packaging for Storing Biologics Outside of the Cold Chain. Adv Healthc Mater 2018;1800220:1-6. Download here.

Guarecuco R, Lu J, McHugh KJ, Norman JJ, Thapa LS, Lydon E, Langer R, Jaklenec A. Immunogenicity of pulsatile-release PLGA microspheres for single-injection vaccination. Vaccine 2018;36:3161-3168. Download here.

McHugh KJ, Nguyen TD, Linehan AR, Yang D, Behrens AM, Rose S, Tochka ZL, Tzeng SY, Norman J, Anselmo AC, Xu X, Tomasic S, Taylor MA, Lu J, Guarecuco R, Langer R, Jaklenec A. Fabrication of fillable microparticles and other complex 3D microstructures. Science 2017;357:1138-42. Featured by BBC News, The Daily Mail, The Guardian, The Independent, New Scientist, Chemical & Engineering News, Engadget, MIT News, Yahoo! News, Fox News, CBS TV & Radio, etc. Download here.

Spencer C, Abend S, McHugh KJ, Saint-Geniez M. Identification of a synergistic interaction between endothelial cells and retinal pigment epithelium. J Cell Mol Med 2017;21:2542-52. Download here.

Anselmo AC, McHugh KJ, Webster J, Langer R, Jaklenec A. Layer-by-layer encapsulation of probiotics for delivery to the microbiome. Adv Mater 2016;28:9486-90. Featured by Popular Science, Phys.org, and MIT News. Download here.

Korley JN, Yazdi S, McHugh K, Kirk J, Anderson J, Putnam D. One-step synthesis, biodegradation and biocompatibility of polyesters based on the metabolic synthon, dihydroxyacetone. Biomaterials 2016;98:41-52. Download here.

Tzeng SY, Guarecuco R, McHugh KJ, Rosenberg EM, Zeng Y, Langer R, Jaklenec A. Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release. J Control Release 2016;233:101-13. Download here.

McHugh KJ, Guarecuco R, Langer R, Jaklenec A. Single-injection vaccines: progress, challenges, and opportunities. J Control Release 2015:219:596-609. Download here.

Pereira MJ, Sundback CA, Lang N, Cho WK, Pomerantseva I, Ouyang B, Tao SL, McHugh K, Mwizerwa O, Vemula PK, Mochel MC, Carter DJ, Borenstein JT, Langer R, Ferreira LS, Karp JM, Masiakos PT. Combined surface micropatterning and reactive chemistry maximizes tissue adhesion with minimal inflammation. Adv Healthc Mater 2014;3:565-71. Featured by Sci Transl Med. Download here.

McHugh KJ, Tao SL, Saint-Geniez M. Porous poly(ε-caprolactone) scaffolds for retinal pigment epithelium transplantation. Invest Ophthalmol Vis Sci 2014;55:1754-62. Download here.

McHugh KJ, Saint-Geniez M, Tao SL. Topographical control of ocular cell types for tissue engineering. J Biomed Mater Res B 2013;101:1571-84. Download here.

Zhang MH, Khankhel AH, McHugh KJ, Saint-Geniez M. Pore-cast scaffold for vascular tissue engineering. 39th Annual Northeast Bioengineering Conference Proceedings 2013:297-8. Download here.

McHugh KJ, Tao SL, Saint-Geniez SL. A novel porous scaffold fabrication technique for epithelial and endothelial tissue engineering. J Mater Sci Mater Med 2013;24:1659-70. Download here.

Cao H, McHugh K, Chew SY, Anderson JM. The topographical effect of electrospun nanofibrous scaffolds on the in vivo and in vitro foreign body reaction. J Biomed Mater Res A 2009;93:1151-9. Download here.

Patents

Jaklenec A, Gates W, Eckhoff PA, Nikolic B, Wood LL Jr., Langer RS, Nguyen TD, Tzeng SY, Norman JJ, McHugh K. Micromolded or 3-D printed pulsatile release vaccine formulations. Filed December 16, 2014, Application Number: US 14/572,631.

McHugh KJ, Saint-Geniez M, Kim L. Predicting retinal degeneration based on three-dimensional modeling of oxygen concentration. Filed April 24, 2013. Application Number: US 14/786,952.

McHugh K, Jaklenec A, Langer RS. Microdevices with complex geometries. Filed September 13, 2017. Application Number: US 62/558,172. Pending.

Jaklenec A, McHugh KJ, Langer RS. Microneedle tattoo patches and use thereof. Filed July 16, 2017. Application Number: US 62/533,081. Pending.